After so many trips and travels to the Mexican interior, do you still get culture shock?
Yes, especially staying a month or longer. I almost always drive in Mexico and it takes me several days to reaccustom myself to California roads. But driving is a different kind of 'shock'; the one I like is the whole enchilada.
We can get up before dawn at our ranch in rural Quintana Roo, Mexico and land in San Jose, California that same night. That's fun, especially if we have spent most of our time at the ranch. Our ranch is pristine, undeveloped and about as far away socially as one can get from Cancun...ha.
The culture shock I remember most was as a teenager after being down in Mexico for six months. That was a really strong effect as I acclimate very quickly to wherever we happen to be...